Losartan vs. lisinopril: Liphapang, ho tšoana, le tse ntle ho uena
Lithethefatsi Vs. MotsoalleKakaretso ea lithethefatsi le liphapang tse kholo | Maemo a phekotsoe | Tshebetso | Ho koahela inshorense le papiso ea litšenyehelo | Litla-morao | Likamano tsa lithethefatsi | Litemoso | LBH
Haeba ue mong oa Maamerika a limilione tse 103 a nang le khatello e phahameng ea mali Mohlomong ngaka ea hau e boletse hore o tla qala ka meriana ho theola khatello ea mali. Losartan le lisinopril ka bobeli ke meriana e tlamang e sebelisoang ho alafa khatello e phahameng ea mali ( khatello ea kelello ). Losartan ke angiotensin II receptor blocker (ARB) le lisinoprile ke angiotensin-converting enzyme inhibitor (ACE inhibitor).
Lithethefatsi tsena ka bobeli li sebetsa karolong ea 'mele e bitsoang renin-angiotensin system empa ka litsela tse fapaneng. Tsamaisong ea renin-angiotensin, ACE inhibitors e thibela ntho e bitsoang angiotensin II hore e se ke ea etsoa. Angiotensin II e fokotsa methapo ea mali mme e eketsa khatello ea mali, ka hona ka ho thibela tlhahiso ea angiotensin II, khatello ea mali ea theoha. Li-ARB li thibela angiotensin II ho tloha ho tlamang ho ea ho li-receptor, ka tsela eo e theola khatello ea mali.
Phapang e kholo lipakeng tsa losartan le lisinopril ke efe?
Losartan ke ARB, e fumanehang ka lebitso le lebitso la letlapa, joalo ka Cozaar (kapa Hyzaar ha e kopane le hydrochlorothiazide, e leng diuretic eo hangata e khutsufalitsoeng joaloka HCTZ). Mefuta e tloaelehileng ea litekanyetso e tloha ho 25 mg ho isa ho 100 mg ka letsatsi.
Lisinopril ke ACE inhibitor e fumanehang ka foromo ea tafole ka mabitso a mabitso Prinivil kapa Zestril (kapa Zestoretic ha e kopane le HCTZ). E boetse e fumaneha e le tharollo ea molomo e bitsoang Qbrelis. Mokhahlelo o tloaelehileng o tloha ho 5 mg ho isa ho 40 mg ka letsatsi.
E RELATED: Lintlha tsa Losartan | Lintlha tsa Lisinopril
| Liphapang tse kholo lipakeng tsa losartan le lisinopril | ||
|---|---|---|
| Losartan | Lisinopril | |
| Sehlopha sa lithethefatsi | Angiotensin receptor blocker (ARB) | ACE inhibitor |
| Boemo ba cha / cha | Cha le generic | Cha le generic |
| Lebitso la lebitso ke mang? | Cozaar Hyzaar (losartan / HCTZ) | Prinivil Zestril Qbrelis (tharollo ea molomo) Zestoretic (lisinopril / HCTZ) |
| Sethethefatsi se kena ka mefuta e fe? | Letlapa (le le leng ebile le kopane le HCTZ) | Letlapa (le le leng ebile le kopane le HCTZ) |
| Tekanyo e tloaelehileng ke efe? | 25 ho isa ho 100 mg ka letsatsi | 5 ho isa ho 40 mg ka letsatsi |
| Kalafo e tloaelehileng e nka nako e kae? | Nako e telele | Nako e telele |
| Ke mang ea sebelisang meriana eo? | Batho ba baholo, bana (ho latela sesupo) | Batho ba baholo, bana (ho latela sesupo) |
U batla litheko tse ntle ka lisinopril?
Ingolise bakeng sa litlhokomeliso tsa litheko tsa lisinopril 'me u fumane hore na theko e fetoha neng!
Fumana litemoso tsa theko
Maemo a phekoloang ke losartan vs. lisinopril
Losartan e bonts'oa kalafo ea khatello ea mali e phahameng (HTN), kapa khatello e phahameng ea mali. E boetse e sebelisetsoa ho fokotsa kotsi ea stroke ho bakuli ba nang le khatello e phahameng ea mali le hypertrophy ea ventricular e ka letsohong le letšehali, hape e sebelisetsoa ho alafa lefu la tsoekere ho bakuli ba bang.
Lisinopril e bontšoa bakeng sa kalafo ea HTN, e le kalafo e tlatselletsang ho ferekaneng ha pelo, le ho ntlafatsa pholoho kamora tlhaselo ea pelo.
Lithethefatsi tsena ka bobeli le tsona li na le tšebeliso e seng ea mabitso, tse boletsoeng ka tlase.
| Boemo | Losartan | Lisinopril |
| Kalafo ea khatello ea kelello ea mali (HTN) | Ho joalo | Ho joalo |
| Fokotsa kotsi ea ho hlaseloa ke stroke ho bakuli ba nang le HTN le ventricular hypertrophy (LVH) | Ho joalo | Off-label |
| Kalafo ea nephropathy ea lefu la tsoekere ka serum creatinine e phahameng le proteinuria ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 le nalane ea HTN | Ho joalo | Off-label |
| Phekolo e kopanetsoeng taolong ea ho hloleha ha pelo ho bakuli ba sa arabeleng ka mokhoa o lekaneng ho diuretics le dijithale | Off-label | Ho joalo |
| Kalafo ea bakuli ba tsitsitseng ba hemodynamically nakong ea lihora tse 24 tsa infarction e bohloko ea myocardial infarction (MI) ho ntlafatsa bophelo | Off-label | Ho joalo |
| Ho hloleha ha pelo ka sekhechana sa ejection se fokotsehileng | Off-label | Off-label |
| Marfan syndrome ho fokotsa sekhahla sa phallo ea aortic | Off-label | Off-label |
| Tsamaiso ea bakuli ba nang le lefu la non-ST-elevation acute coronary syndrome | Off-label | Off-label |
| Ba amohelang liphio | Off-label | Off-label (ho bakuli ba nang le lefu la kamora 'transry erythrocytosis) |
| Bakuli ba nang le lefu la liphio le sa foleng | Off-label (ho bakuli ba nang le lefu la tsoekere) | Off-label (bakuli ba lefu la tsoekere kapa ba nondiabetic) |
| Boloetse bo tsitsitseng ba methapo ea pelo | Off-label | Off-label |
Na losartan kapa lisinopril e sebetsa hantle?
Ha ho hlahlojoa lithuto tse 61 tse bapisang li-ARB (ho kenyeletsoa losartan) le ACE inhibitors (ho kenyeletsoa lisinopril), mefuta ka bobeli ea lithethefatsi e fumanoe e na le litlamorao tse ts'oanang tsa nako e telele khatello ea mali. Bangoli ba boetse ba fihletse qeto ea hore mekhahlelo e 'meli ea lithethefatsi e na le phello e lekanang lefung, liketsahalong tsa pelo, liketsahalong tse mpe tse mpe, boleng ba bophelo, le lisosa tse kotsi tse kang lipid, lefu la tsoekere, le boima ba' mele le tšebetso.
Ka nyane ho ithuta ea bakuli ba nang le lefu la liphio, losartan le lisinopril li bile le litlamorao tse tšoanang ts'ebetsong ea liphio le khatello ea mali.
Moriana o sebetsang ka ho fetisisa ho uena o lokela ho khethoa ke ngaka ea hau, ea ka shebang setšoantšo se felletseng sa maemo a hau a bongaka, nalane le meriana e meng eo o e nkang.
Ho bapisa le ho bapisa litšenyehelo tsa losartan vs. lisinopril
Li-losartan le lisinopril li koahetsoe ke inshorense le Medicare Part D ka mokhoa o tloaelehileng. Mefuta ea lebitso la lebitso e ka koaheloa ka copay e phahameng. Litsenyehelo tsa kantle ho pokotho tsa matlapa a 30 a losartan 100 mg li ka tloha ho $ 28- $ 70, mme Medicare Part D copay e ka ba $ 0- $ 13. Ka setlankane sa SingleCare, litefiso ke $ 9- $ 16 ho latela famasi e nkang karolo. Litsenyehelo tsa kantle ho pokello ea matlapa a 30 a lisinopril tse 10 mg e ka ba $ 15, mme Medicare Part D copay e ka ba $ 0- $ 7. U ka boloka chelete ho lisinopril ka ho sebelisa karete ea theolelo ea SingleCare kapa setlankane.
Leka karete ea theolelo ea SingleCare
| Losartan | Lisinopril | |
| E koahetsoe ka inshorense? | Ho joalo | Ho joalo |
| E koahetsoeng ke Medicare? | Ho joalo | Ho joalo |
| Tekanyo e tloaelehileng | Lipilisi tsa # 90, 100 mg | Lipilisi tsa # 90, 20 mg |
| E tloaelehileng ea Medicare copay | $ 0- $ 13 | $ 0- $ 7 |
| Litsenyehelo tsa SingleCare | $ 28- $ 70 | $ 9- $ 26 |
Litla-morao tse tloaelehileng tsa losartan vs. lisinopril
Litla-morao tse tloaelehileng tsa losartan li kenyelletsa ho khohlela, ho tsekela, tšoaetso e phahameng ea ho hema, mokhathala le lets'ollo.
Litla-morao tse tloaelehileng tsa lisinopril li kenyelletsa ho khohlela, ho tsekela, hlooho, mokhathala le lets'ollo.
Litla-morao tse ling li ka hlaha. Ikopanye le setsebi sa tlhokomelo ea bophelo bakeng sa lenane le felletseng la litla-morao.
| Losartan | Lisinopril | |||
| Litla-morao | E sebetsa? | Maqhubu | E sebetsa? | Maqhubu |
| Khohlela | Ho joalo | 17-29% | Ho joalo | 3.5-69% |
| Botsoa | Ho joalo | 3% | Ho joalo | 5.4% |
| Phefumoloho e kaholimo tshwaetso | Ho joalo | 8% | Ho joalo | 2.1% |
| Ho ferekana ka nko | Ho joalo | tse peli% | Ho joalo | 0.4% |
| Bohloko ba morao | Ho joalo | tse peli% | Che | - |
| Mokhathala | Ho joalo | > 4% | Ho joalo | 2.5% |
| Letšollo | Ho joalo | > 4% | Ho joalo | 2.7% |
| Ho nyekeloa | Ho joalo | Ha e tlalehiloe | Ho joalo | tse peli% |
| Ho opeloa ke hlooho | Ho joalo | Ha e tlalehiloe | Ho joalo | 5.7% |
Mohloli: DailyMed (losartan) , Letsatsi le Letsatsi (lisinopril)
Likamano tsa lithethefatsi le losartan vs. lisinopril
Losartan kapa lisinopril ha ea lokela ho sebelisoa ka potasiamo kapa meriana e meng e eketsang potasiamo (joalo ka potassium-sparing diuretics), ka lebaka la kotsi ea hyperkalemia. Ntle le moo, botsa ngaka ea hau ka potasiamo lijong tsa hau le hore na u lokela ho qoba lijo tse nang le potasiamo tse ngata le lintho tse ling tse kenang letsoai tse nang le potasiamo.
Li-NSAID (lithethefatsi tse seng khahlanong le ho ruruha) ha lia lokela ho sebelisoa hammoho le losartan kapa lisinopril, hobane kopanyo e ka baka kotsi ea liphio kapa ho hloleha ha liphio.
Losartan kapa lisinopril ha ea lokela ho sebelisoa hammoho le ACE inhibitor, ARB, kapa Tekturna (aliskiren) hobane kopanyo e eketsa kotsi ea khatello e tlase ea mali, potasiamo e phahameng, ho akheha, tšenyo ea liphio, kapa ho hloleha ha liphio.
Ikopanye le mofani oa tlhokomelo ea bophelo bakeng sa lenane le felletseng la litšebelisano tsa lithethefatsi.
| Lithethefatsi | Sehlopha sa Lithethefatsi | Losartan | Lisinopril |
| Potasiamo | Electrolyte | Ho joalo | Ho joalo |
| Bohareng (amiloride) Aldactone (spironolactone) Dyrenium (triamterene) Inspra (eplerenone) | Li-diuretics tse bolokang potasiamo | Ho joalo | Ho joalo |
| Aspirine Motrin, Advil (ibuprofen) Aleve (naproxen) Mobic (meloxicam) Selebrex (celecoxib) Phomola (nabumetone) | Li-NSAID | Ho joalo | Ho joalo |
| Vasotec (enalapril) Lotensin (benazepril) Sephetho (quinapril) Altace (ramipril) | ACE inhibitors | Ho joalo | Ho joalo |
| Diovan (valsartan) Edarbi Ho hlasela (candesartan) Se-avapro (irbesartan) Micardis (telmisartan) Benicar (olmesartan) | Li-ARB | Ho joalo | Ho joalo |
| Tekturna (aliskiren) | Renin inhibitor | Ho joalo | Ho joalo |
| Lithium | Moemeli oa Antimanic | Ho joalo | Ho joalo |
Litemoso tsa losartan le lisinopril
Losartan le lisinopril ka bobeli ba tla le tlhokomeliso e nang le mabokose, e leng temoso e matla ka ho fetesisa joalo ka ha ho hlokahala ke FDA. Lithethefatsi (tse kang losartan le lisinopril) tse sebetsang tsamaisong ea renin-angiotensin li ka baka likotsi tse mpe tsa lesea / likoli tsa tsoalo kapa lefu mme li lokela ho emisoa hang ha bokhachane bo thehiloe.
Litemoso tse ling tse sebetsang ho losartan le lisinopril:
- Bakuli ba felloe ke metsi 'meleng kapa ba noang diuretics ba ka ba le khatello e tlase ea mali (hypotension).
- Liphetoho mosebetsing oa renal, ho kenyelletsa le ho hloleha ho matla ha renal, li ka hlaha. Kotsi e phahame ho bakuli ba nang le mathata a liphio kapa ho hloleha ho hoholo ha pelo. Bakuli bana e kanna ea se be mokhethoa oa ACE inhibitor kapa ARB. Haeba e 'ngoe ea lithethefatsi tsena e qala, ts'ebetso ea liphio e lokela ho beoa leihlo.
- Maemo a potasiamo a lokela ho behwa leihlo.
Lisinopril e na le litemoso tse ling:
- Ho na le monyetla oa ho ba le anaphylactic reaction (e matla ea alejiki reaction), ho kenyelletsa angioedema (ho ruruha) ha sefahleho, lipheletsong, melomo, leleme, glottis, le / kapa larynx. Karabelo ena e ka hlaha neng kapa neng nakong ea kalafo. Angioedema e amanang le edema ea laryngeal e ka bolaea. Moo ho amehang leleme, glottis kapa larynx, tse ka bakang tšitiso ea sefofane, ho hlokahala kalafo ea tšohanyetso. Lisinopril e lokela ho emisoa haeba liphetoho tsena li etsahala.
- Ho na le kotsi e nyane ea mathata a sebete; Li-enzyme tsa sebete li lokela ho behoa leihlo.
- Ka lebaka la ho senyeha ha ntho e bitsoang bradykinin, ho khohlela ho omeletseng ho ka hlaha. Hang ha meriana e emisitsoe, khohlela e lokela ho fela.
Lipotso tse botsoang khafetsa ka losartan le lisinopril
Losartan ke eng?
Losartan ke angiotensin receptor blocker e thusang ho fokotsa khatello ea mali. E ka sebelisoa hape bakeng sa maemo a mang a fapaneng, a boletsoeng kaholimo.
Lisinopril ke eng?
Lisinopril ke ACE inhibitor e thusang ho fokotsa khatello ea mali. E boetse e sebelisetsoa maemo a mang a bongaka, a boletsoeng kaholimo.
Na losartan vs. lisinopril lia tšoana?
Le ha meriana ka bobeli e sebetsa tsamaisong ea renin-angiotensin, e sebetsa libakeng tse fapaneng tsa sistimi, empa meriana ka bobeli e theola khatello ea mali mme e sebelisetsoa maemo a mang a pelo kapa a liphio. Li boetse li na le liphapang tse ling tsa tekanyetso, litemoso le theko.
Mefuta e meng e tloaelehileng ea ACE inhibitors (joalo ka lisinopril) eo e ka 'nang eaba u utloile ka eona e kenyelletsa Lotensin (benazepril), Vasotec (enalapril), Accupril (quinapril), le Altace (ramipril).
Li-ARB tse ling (joalo ka losartan) eo e kanna eaba u utloile ka eona e kenyelletsa Edarbi (azilsartan - ha ho na generic e fumanehang), Atacand (candesartan), Avapro (irbesartan), Micardis (telmisartan), Diovan (valsartan), le Benicar (olmesartan).
Na losartan kapa lisinopril li betere?
Boithuto bo bontšitse li-ARB joalo ka losartan le ACE inhibitors joalo ka lisinopril ho ba le litlamorao tse tšoanang. Ikopanye le mofani oa tlhokomelo ea bophelo ho bona hore na e 'ngoe ea meriana ena e u loketse.
Na nka sebelisa losartan kapa lisinopril ha ke le moimana?
Losartan kapa lisinopril HA E LOKELA ho nkoa ha e le moimana. Lithethefatsi tsena ka bobeli li kotsi haholo ho lesea le ntseng le hola, 'me li ka baka likoli tse tebileng tsa tlhaho kapa le lefu ho lesea le ka popelong. Haeba u se u ntse u nka losartan kapa lisinopril 'me u fumana hore u imme, etela ngaka hang-hang.
Nka sebelisa losartan kapa lisinopril ka joala?
Ho noa joala ha o ntse o noa losartan kapa lisinopril ho ka eketsa ho tsekela, kapa ha ama khatello ea mali kapa maemo a mang a bongaka. Ikopanye le ngaka ea hau mabapi le ts'ebeliso ea joala le losartan kapa lisinopril.
Na ke lokela ho nka lisinopril le losartan hammoho?
Che. Le ha meriana e meng ea khatello ea mali e sebelisoa hammoho (joalo ka losartan kapa lisinopril hammoho le diuretic), lisinopril le losartan ha lia lokela ho nkoa hammoho. Ho etsa joalo ho eketsa kotsi ea khatello e tlase ea mali, potasiamo e phahameng le ho lemala ha liphio, tse ka bang mpe haholo kapa tsa ba tsa bolaea.
Na losartan ke ACE inhibitor kapa beta blocker?
Losartan ke blocker ea angiotensin receptor blocker. Ha se inhibitor ea ACE kapa beta blocker.
Na losartan e baka litla-morao tse fokolang ho feta lisinopril?
Lithethefatsi tsena ka bobeli li na le litla-morao tse tšoanang, leha lisinopril e na le monyetla oa ho baka khohlela e ommeng mme e na le kotsi ea angioedema (e matla ea alejiki). Ikopanye le setsebi sa tlhokomelo ea bophelo bakeng sa lenane le felletseng la litla-morao.
