Atorvastatin vs. simvastatin: Liphapang, ho tšoana, le hore na ho molemo ho uena
Lithethefatsi Vs. MotsoalleKakaretso ea lithethefatsi le liphapang tse kholo | Maemo a phekotsoe | Tshebetso | Ho koahela inshorense le papiso ea litšenyehelo | Litla-morao | Likamano tsa lithethefatsi | Litemoso | LBH
Atorvastatin le simvastatin ke lithethefatsi tse peli tse atisang ho beoa tsa statin tse phekolang k'holeseterole e phahameng. Ngaka ea hau e ka u fa e 'ngoe ea meriana ena haeba u na le LDL (low-density lipoprotein) cholesterol, e tsejoang hape e le cholesterol e mpe. Ka ho theola maemo a k'holeseterole, atorvastatin kapa simvastatin e ka thusa ho fokotsa kotsi ea lefu la pelo le stroke.
Haholo-holo, atorvastatin le simvastatin li sebetsa joalo ka HMG-CoA reductase inhibitors. Ka ho thibela enzyme ea HMG-CoA reductase, tsena liemahale fokotsa tlhahiso ea k'holeseterole sebeteng. 'Mele o na le k'holeseterole e fokolang maling,' me o khona ho khutlisa k'holeseterole e feteletseng le ho theola maemo a k'holeseterole ka kakaretso.
Atorvastatin le simvastatin li ka sebetsa ka litsela tse ts'oanang empa li na le liphapang tse fapaneng litekanyetsong, tsamaisong le litlamorao tse ka bang teng.
Phapang e kholo ke efe lipakeng tsa atorvastatin le simvastatin?
Atorvastatin e boetse e tsejoa ka lebitso la eona, Lipitor, e neng e amohetsoe ke FDA ka 1996. Har'a lits'ebeliso tse ling, e laetsoe ho fokotsa kotsi ea lefu la pelo kapa stroke ho ba nang le lefu la pelo .
Atorvastatin (Atorvastatin ke eng?) E na le halofo ea bophelo bo bolelele ba lihora tse 14. Lithethefatsi li sebetsa hang ha li monya, 'me tšebetso ea eona ea ho theola lipid e ka tšoarella Lihora tse 20 ho isa ho tse 30 kamora tsamaiso. Hammoho le rosuvastatin, kapa Crestor, atorvastatin ke sethethefatsi se matla ho feta li-statin tse ling tse kang simvastatin le pravastatin.
Atorvastatin e fumaneha ka 10 mg, 20 mg, 40 mg, le matlapa a 80 mg. Tekanyo e khothalletsoang ea ho qala ke 10 kapa 20 mg hang ka letsatsi leha tekanyetso e tloaelehileng e ka tloha ho 10 ho isa ho 80 mg hang ka letsatsi. Atorvastatin e ka nkoa ka nako efe kapa efe ea letsatsi.
Simvastatin (Simvastatin ke eng?) E tsejoa hape ka lebitso la eona, Zocor. Ha e bapisoa le atorvastatin, simvastatin ke sethethefatsi sa khale se ileng sa amoheloa pele ke FDA ho 1991. Joalo ka li-statin tse ling, e sebelisetsoa ho fokotsa kotsi ea lefu la pelo le stroke ho ba nang le likotsi tsa pelo.
U batla theko e ntle ho simvastatin?
Ingolise bakeng sa tlhokomeliso ea theko ea simvastatin 'me u fumane hore na theko e fetoha neng!
Fumana litemoso tsa theko
Ho fapana le atorvastatin, simvastatin ke sethethefatsi . Ho bolelang hore ha e sebetse ho fihlela e ts'oaetsoa sebeteng. Kamora ho sebetsoa, simvastatin e fetoha sebopeho sa eona se sebetsang, simvastatin acid, e nang le halofo ea bophelo ba nako e ka etsang hora ho isa ho tse peli.
Simvastatin e fumaneha ka matla a 5 mg, 10 mg, 20 mg, 40 mg, le 80 mg. Tekanyo e khothalletsoang ea ho qala ke 10 kapa 20 mg hang ka letsatsi, mme tekanyetso e tloaelehileng e ka tloha ho 5 ho isa ho 40 mg ka letsatsi. Simvastatin e kgothaletswa ho nkoa bosiu.
| Phapang e kholo lipakeng tsa atorvastatin le simvastatin | ||
|---|---|---|
| Atorvastatin | Simvastatin | |
| Sehlopha sa lithethefatsi | HMG-CoA reductase inhibitor Statin | HMG-CoA reductase inhibitor Statin |
| Boemo ba cha / cha | Mofuta oa brand le generic oa fumaneha | Mofuta oa brand le generic oa fumaneha |
| Lebitso la lebitso ke mang? | Lipitor | Tsokor |
| Sethethefatsi se kena ka mefuta e fe? | Letlapa la molomo | Letlapa la molomo |
| Tekanyo e tloaelehileng ke efe? | 10 ho isa ho 80 mg hang ka letsatsi | 5 ho isa ho 40 mg hang ka letsatsi |
| Kalafo e tloaelehileng e nka nako e kae? | Kalafo ea atorvastatin ke ea nako e telele ho sebetsana le maemo a k'holeseterole le ho boloka kotsi e tlase ea tlhaselo ea pelo le stroke. | Kalafo ka simvastatin ke ea nako e telele ho sebetsana le maemo a k'holeseterole le ho boloka kotsi e tlase ea tlhaselo ea pelo le stroke. |
| Ke mang ea sebelisang meriana eo? | Batho ba baholo; bana le bacha ba lilemo li 10 ho isa ho tse 17 ba nang le heterozygous family hypercholesterolemia (HeFH) | Batho ba baholo; bana le bacha ba lilemo li 10 ho isa ho tse 17 ba nang le heterozygous family hypercholesterolemia (HeFH) |
Maemo a phekoloang ke atorvastatin le simvastatin
Atorvastatin le simvastatin li sebelisetsoa merero e ts'oanang. Ka bobeli li phekola maemo a phahameng a k'holeseterole (hypercholesterolemia), maemo a phahameng a lipid (hyperlipoproteinemia), le maemo a phahameng a triglyceride (hypertriglyceridemia). Ka nako e ts'oanang, li-statin li ka thusa ho eketsa k'holeseterole ea HDL, mofuta oa k'holeseterole e ntle e nang le ts'ireletso khahlano le lefu la pelo.
Atorvastatin le simvastatin le tsona li ka fokotsa menyetla ea ho hlaseloa ke lefu la pelo le stroke ka tse latelang:
- Batho ba baholo ba se nang lefu la pelo (CHD) ba nang le mabaka a mangata a kotsi
- Batho ba baholo ba nang le lefu la tsoekere la Mofuta oa 2 ntle le CHD, empa ba na le mabaka a mangata a kotsi
- Batho ba baholo ba nang le CHD e fumanoeng
Lisosa tse kotsi tsa liketsahalo tsa pelo li ka kenyelletsa khatello e phahameng ea mali (khatello ea kelello) le tsoekere e phahameng maling (lefu la tsoekere).
Atorvastatin le simvastatin li ka fokotsa maemo a k'holeseterole le lipid ho ba nang le mathata a lipid liphatsa tsa lefutso , joalo ka homozygous family hypercholesterolemia (HoFH). Li-statin tsena li ka phekola bana le bacha (ba lilemo li 10-17) ba nang le heterozygous family hypercholesterolemia (HeFH).
Kalafo ea atherosclerosis, kapa mafura a bolokiloeng maboteng a methapo ea mali, ke lebaka le leng leo ka lona atorvastatin kapa simvastatin e ka laeloang. Ka ho fokotsa letlapa marakong a methapo ea mali, li-statin tsena li ka thusa ho fokotsa matšoao a kang bohloko ba sefuba (angina).
| Boemo | Atorvastatin | Simvastatin |
| Hypercholesterolemia | Ho joalo | Ho joalo |
| Hyperlipoproteinemia | Ho joalo | Ho joalo |
| Hypertriglyceridemia | Ho joalo | Ho joalo |
| Lefu la pelo le thibelo ea stroke | Ho joalo | Ho joalo |
| Matšoafo | Ho joalo | Ho joalo |
Na atorvastatin kapa simvastatin e sebetsa hantle ho feta?
Atorvastatin le simvastatin ka bobeli ke meriana e sebetsang ea statin. Boithuto bo bontšitse hore ba noang meriana ea bona ea statin bonyane 90% ea nako ho ba le kotsi e fokotsehileng ea 45% ea ho shoa ke lefu la pelo, stroke, kapa sesosa sefe kapa sefe. Ka kakaretso, li-statin li sebetsa haholo ho fokotsa maemo a k'holeseterole le ho fokotsa maemo a lefu la pelo le stroke.
Ha ho liteko tse matla tsa hlooho le hlooho tse bapisoang le atorvastatin le simvastatin tse kileng tsa etsoa. Leha ho le joalo, atorvastatin e nkuoa e le sethethefatsi se matla ho feta simvastatin. Ka phuputso e 'ngoe ea morao tjena ea papiso , atorvastatin e fumanoe e sebetsa haholo ho theoleng LDL cholesterol (LDL-C) ho feta simvastatin. Phuputso ena e hlophisitse liphetho ho tsoa litekong tse 50 tse sa sebetseng, tsa liteko tsa bongaka, mme ea bapisa lithethefatsi tse ling tsa statin tse kang fluvastatin, pravastatin, rosuvastatin le lovastatin. Rosuvastatin e ne e na le matla a phahameng ka ho fetisisa a ho theola maemo a LDL thutong.
Ka bonngoe tlhahlobo e hlophisehileng , Liphuputso tse 75 tse fapaneng tse bapisoang le meriana ea li-statin li ile tsa hlahlojoa. Ho latela liphetho tsa sehlopha sa boithuto, tekanyetso ea letsatsi le letsatsi ea atorvastatin 10 mg e ka fokotsa cholesterol ea LDL ka 30% -40% ha tekanyetso ea letsatsi le letsatsi ea simvastatin 10 mg e ka fokotsa cholesterol ea LDL ka 20% -30%. Leha ho le joalo, litlamorao tsa kliniki ea phapang ena li kanna tsa se be bohlokoa.
Ikopanye le mofani oa tlhokomelo ea bophelo ho fumana kalafo e nepahetseng bakeng sa hau. Katleho ea li-statin e tla itšetleha ka nalane ea hau ea bongaka le ea lelapa, har'a lintlha tse ling.
Ho koahela le ho bapisa litšenyehelo tsa atorvastatin vs simvastatin?
Atorvastatin e fumaneha e le sethethefatsi se tloaelehileng se atisang ho koaheloa ke Medicare le merero e meng ea inshorense. E laeloa e le pilisi ea letsatsi le letsatsi e ka fanoang ka phepelo ea matsatsi a 30 kapa ea matsatsi a 90. Theko ea karolelano ea chelete ea atorvastatin e ka fihla ho $ 250. Leha ho le joalo, theko e ka theoleloa ho $ 15 ka setlankane sa SingleCare atorvastatin.
Simvastatin e boetse e fumaneha e le sethethefatsi se tloaelehileng. Joaloka seemahale se atisang ho laeloa, simvastatin hangata e koaheloa ke Medicare le merero ea inshorense. Theko e tloaelehileng ea thekiso ea simvastatin e ka ba $ 470. Leha ho le joalo, ka karete ea litheolelo bakeng sa simvastatin, joalo ka SingleCare, u ka lebella ho lefa chelete e ka tlase ho $ 10 bakeng sa phepelo ea matsatsi a 30 ea lipilisi tsa 20 mg li-pharmacy tse nkang karolo.
| Atorvastatin | Simvastatin | |
| E koahetsoe ka inshorense? | Ho joalo | Ho joalo |
| E koahetsoe ka tloaelo ke Medicare Part D? | Ho joalo | Ho joalo |
| Tekanyo e tloaelehileng | 10 mg hang ka letsatsi (bongata ba 30) | 20 mg hang ka letsatsi (bongata ba 30) |
| E tloaelehileng ea Medicare copay | $ 0- $ 16 | $ 0- $ 9 |
| Litsenyehelo tsa SingleCare | $ 15 + | $ 10 + |
Fumana karete ea theolelo ea litlama
Litla-morao tse tloaelehileng tsa atorvastatin vs simvastatin?
Litla-morao tse tloaelehileng tsa li-statin, joalo ka atorvastatin le simvastatin, li kenyelletsa mathata a tšilo ea lijo a kang letšollo, ho nyehlisa le ho nyekeloa ke pelo. Litla-morao tse ling li kenyelletsa ho ba le botsoa le ho ruruha ha matsoho, maoto kapa maoto (edema). Lipolelo li ka baka bohloko ba mesifa (myalgia) kapa bofokoli ba mesifa (myopathy).
Kotsi ea bohloko ba mesifa e eketseha ka litekanyetso tse phahameng tsa li-statin. Leha ho le joalo, ha e bapisoa le atorvastatin, simvastatin e nkuoa e le kotsing e kholo ea myalgia. Batho ba bang le bona ba ka ba le file ea liphatsa tsa lefutso tsa myalgia ho tloha simvastatin. Le ha li-statin tsohle li na le kotsi ea ho baka bohloko ba mesifa e le litlamorao, FDA e fokolitse tšebeliso ea lipilisi tsa simvastatin 80 mg ka lebaka la kotsi e eketsehang.
Litla-morao tse ling tse tloaelehileng li ka fumanoa tafoleng e ka tlase.
| Atorvastatin | Simvastatin | |||
| Phello e lehlakoreng | E sebetsa? | Maqhubu | E sebetsa? | Maqhubu |
| Bohloko bo kopaneng | Ho joalo | 7% | Ho joalo | 0.1% |
| Letšollo | Ho joalo | 7% | Ho joalo | * |
| Ho sokela | Che | - | Ho joalo | tse peli% |
| Qoqelo | Ho joalo | 5% | Ho joalo | * |
| Ho nyekeloa | Ho joalo | 4% | Ho joalo | 6% |
| Bohloko ba mesifa | Ho joalo | 4% | Ho joalo | 4% |
| Tšoaetso ea pampiri ea moroto | Ho joalo | 6% | Ho joalo | 3% |
| Nasopharyngitis | Ho joalo | 8% | Che | - |
| Botsoa | Ho joalo | * | Ho joalo | 5% |
| Edema | Ho joalo | * | Ho joalo | 3% |
* ha e tlalehe
Maqhubu ha a ipapise le tlhaiso-leseling e tsoang hloohong ho ea hloohong. Sena e kanna ea ba lenane le felletseng la litlamorao tse bohloko tse ka bang teng. Ka kopo sheba ngaka ea hau kapa mofani oa tlhokomelo ea bophelo ho ithuta haholoanyane.
Mohloli: DailyMed ( Atorvastatin ), Letsatsi le Letsatsi ( Simvastatin )
Likamano tsa lithethefatsi tsa atorvastatin vs simvastatin
Atorvastatin le simvastatin li sebetsoa haholo sebeteng ke enzyme ea CYP3A4. Lithethefatsi tse thibelang kapa tse thibelang enzyme ena li ka baka maemo a eketsehileng a atorvastatin kapa simvastatin maling. Ha e nkoa ka CYP3A4 inhibitor e kang clarithromycin kapa itraconazole, atorvastatin e ka baka kotsi e kholo ea bohloko ba mesifa (myalgia) kapa bofokoli ba mesifa (myopathy). Lero la tholoana ea morara hape ke CYP3A4 inhibitor e ka eketsang maemo a atorvastatin le simvastatin. Ka lehlakoreng le leng, lithethefatsi tse kang rifampin le carbamazepine ke li-inducers tsa CYP3A4 tse ka fokotsang maemo a atorvastatin le simvastatin 'meleng.
Protease inhibitors, joalo ka ritonavir le lopinavir, li ka baka maemo a eketsehileng a li-statin 'meleng. Litekanyetso tse phahameng tsa li-statin maling li ka lebisa kotsing e kholo ea litlamorao, ho kenyeletsoa myalgia. Lithethefatsi tse matlafatsang le niacin le tsona li ka eketsa menyetla ea myalgia ha e nkuoa ka atorvastatin kapa simvastatin.
Ho nka atorvastatin ka lithibela-pelehi ka molomo ho ka baka keketseho ea mali a meriana ea lithibela-pelehi.
Ho nkuoa li-statin tse nang le warfarin ho tlalehiloe ho baka maemo a eketsehileng a warfarin le kotsi e kholo ea ho tsoa mali. Leha ho le joalo, atorvastatin e joalo ha ho na monyetla oa ho kena-kenana ka litlamorao tsa warfarin.
| Lithethefatsi | Sehlopha sa lithethefatsi | Atorvastatin | Simvastatin |
| Clarithromycin Erythromycin Itraconazole Ketoconazole Lero la tholoana ea morara | CYP3A4 inhibitors | Ho joalo | Ho joalo |
| Rifampin Carbamazepine | Li-inducers tsa CYP3A4 | Ho joalo | Ho joalo |
| Ritonavir Lopinavir Simeprevir Darunavir | Protease inhibitors | Ho joalo | Ho joalo |
| Gemfibrozil Fenofibrate | Likhoele | Ho joalo | Ho joalo |
| Niacin | Antihyperlipidemic | Ho joalo | Ho joalo |
| Digoxin | Glycoside ea pelo | Ho joalo | Ho joalo |
| Norethindrone Ethinyl estradiol | Dithibela pelehi | Ho joalo | Che |
| Warfarin | Anticoagulant | Che | Ho joalo |
Ikopanye le setsebi sa tlhokomelo ea bophelo bakeng sa litšebelisano tse ling tsa lithethefatsi.
Litemoso tsa atorvastatin le simvastatin
Ka bobeli atorvastatin le simvastatin li ka baka liketsahalo tse bohloko tse amanang le bohloko ba mesifa (myalgia) kapa bofokoli ba mesifa (myopathy). Maemong a boima, li-statin tsena li ka baka rhabdomyolysis, kapa ho senyeha ka potlako ha mesifa ea masapo. Mofuta o sa tloaelehang oa myopathy, o bitsoang 'immune-mediated necrotizing myopathy' (IMNM) le eona e tlalehiloe ka ts'ebeliso ea statin.
Atorvastatin le simvastatin li sebelisoa haholo sebeteng. Ka hona, ts'ebeliso ea bona e ka baka ho sa tloaelehang maemong a enzyme ea sebete. Li-enzyme tsa sebete li lokela ho hlahlojoa ho pholletsa le kalafo ea statin. Batho ba nang le lefu la sebete le bona ba lokela ho beoa leihlo kapa ba qobe li-statin ka botlalo.
Atorvastatin le simvastatin li lokela ho qojoa ho bakhachane le bo-mme ba anyesang. Li-statin tsena li kanna tsa ba le kotsi e eketsehileng ea bofokoli ba tsoalo.
Lipotso tse botsoang khafetsa mabapi le atorvastatin vs simvastatin?
Atorvastatin ke eng?
Atorvastatin, eo hape e tsejoang ka lebitso la eona Lipitor, ke moriana oa statin o sebelisetsoang ho theola k'holeseterole le ho fokotsa kotsi ea lefu la pelo le stroke. Lebelo le tloaelehileng la atorvastatin le pakeng tsa 10 le 80 mg ka letsatsi. Atorvastatin e na le halofo ea bophelo bo bolelele ba lihora tse 14 mme e ka nkoa nako efe kapa efe ea letsatsi.
Simvastatin ke eng?
Simvastatin e boetse e tsejoa ka lebitso la eona, Zocor. Ke meriana ea statin e ka fokotsang maemo a k'holeseterole, eo le eona e ka thusang ho fokotsa kotsi ea lefu la pelo le stroke. Mefuta e tloaelehileng ea lethal dose ea simvastatin e mehlano ho isa ho 40 mg ka letsatsi. Simvastatin e na le halofo ea bophelo haufinyane mme ho kgothaletswa hore e nwe mantsiboea.
Na atorvastatin le simvastatin lia tšoana?
Atorvastatin le simvastatin ka bobeli ke ba sehlopha sa lithethefatsi se bitsoang HMG-CoA reductase inhibitors, kapa li-statin. Ka bobeli li sebelisoa ho theola li-cholesterol tsa LDL. Leha ho le joalo, li na le liphapang tse ling ho matla a teng le hore na li nkuoa joang.
Na atorvastatin kapa simvastatin li betere?
Atorvastatin le simvastatin ka bobeli ke lithethefatsi tse sebetsang tsa ho theola k'holeseterole ea mali. Leha ho le joalo, atorvastatin e nkuoa e le statin e matla ho feta. Atorvastatin e nka nako e teletsana 'meleng mme e ka nkoa hoseng kapa bosiu. Simvastatin e na le kotsi e kholo ea bohloko ba mesifa kapa bofokoli ho feta atorvastatin, haholoholo litekanyetsong tse phahameng. Ngaka e fanang ka ngaka e tla etsa qeto ea molao o sebetsang ka ho fetisisa ho latela maemo.
A na nka sebelisa atorvastatin kapa simvastatin ha ke le moimana?
Atorvastatin le simvastatin ha lia lokela ho sebelisoa nakong ea bokhachane. Maemo a k'holeseterole a ka eketseha nakong ea bokhachane 'me a hlokahala ho tšehetsa lesea le ntseng le hola. Ka hona, ha ho na molemo oa ho nka li-statin tsena nakong ea bokhachane. Li ka baka tšenyo ea lesea nakong ea bokhachane.
A na nka sebelisa atorvastatin kapa simvastatin le joala?
Ho latela litsebi tsa lefu la pelo , tšebeliso ea joala ka tekano ka kakaretso e bolokehile ha ho sebelisoa statin. Ho noa joala haholo ho lebisitseng lefung la sebete ke moo mathata a ka hlahang. Li-enzyme tsa sebete li lokela ho hlahlojoa nakong eohle ea kalafo ka statin.
Ke statin efe e nang le litla-morao tse fokolang?
Lipolelo ka kakaretso li bolokehile ha li na litla-morao tse fokolang. Ho latela American Heart Association (AHA), melemo ea liemahale ho feta kotsi e ka bang teng ea litla-morao. Leha ho le joalo, li-statin tse ling, joalo ka pravastatin le fluvastatin , e kanna ea ba le kotsi e tlase ea myalgia ho feta simvastatin le atorvastatin. Ha li bapisoa le li-statin tse fanoeng ka tekanyetso e tlase, li-statin tse nang le litekanyetso tse phahameng li na le monyetla oa ho baka litla-morao. Mohlala, tekanyetso ea 80 mg ea simvastatin e na le kotsi e kholo ea ho baka myalgia. Ka lebaka lena, FDA e lekanyelitse tekanyetso ena ea simvastatin ho batho ba itseng feela.
Litla-morao tsa atorvastatin ke life?
Litla-morao tsa nako e telele tsa kalafo ea statin li ka fapana ho latela motho. Nako e telele litla-morao tsa li-statins e ka kenyelletsa bohloko ba mesifa, tšenyo ea sebete, tsoekere e eketsehileng maling le mathata a ho hopola. Leha ho le joalo, kotsi ea litla-morao tsa nako e telele e nkuoa e le tlase ha moriana o laeloa le ho tsamaisoa hantle.
Na atorvastatin e mpe bakeng sa liphio tsa hau?
Tekanyo ea atorvastatin ha e hloke ho fetoloa ho ba nang le mathata a liphio. Ho batho ba bang ba nang le mathata a matla a liphio, ts'ebeliso ea atorvastatin e kanna ea hloka ho beoa leihlo.
Ka kakaretso, atorvastatin ha e kotsi liphio. Leha ho le joalo, tšebeliso ea atorvastatin e ka lebisa kotsing e kholo ea rhabdomyolysis, e ka lebisang ho hloleha ha renal maemong a boima. Bua le ngaka ea hau haeba u na le nalane ea mathata a liphio pele u qala ka sethethefatsi sa statin.
