Pravastatin vs. Lipitor: Liphapang, ho tšoana, 'me ke hofe ho u loketseng
Lithethefatsi Vs. MotsoalleKakaretso ea lithethefatsi le liphapang tse kholo | Maemo a phekotsoe | Tshebetso | Ho koahela inshorense le papiso ea litšenyehelo | Litla-morao | Likamano tsa lithethefatsi | Litemoso | LBH
Pravastatin le Lipitor (atorvastatin) ke meriana ea ngaka e sebelisetsoang ho phekola k'holeseterole e phahameng. Likarolo tsa k'holeseterole tse phahameng ho feta tse tloaelehileng li ka eketsa kotsi ea lefu la pelo, lefu la methapo, lefu la pelo le stroke. Cholesterol e hlahisoa haholo sebeteng ka enzyme ea HMG-CoA reductase.
Pravastatin le atorvastatin ke lithethefatsi tse khetholloang e le HMG-CoA reductase inhibitors. E tsejoang hape e le lithethefatsi tsa statin, pravastatin le atorvastatin inhibit, kapa block, enzyme ea HMG-CoA reductase, e lebisang ho fokotseheng ha tlhahiso ea k'holeseterole sebeteng. Ts'ebeliso ea li-statin le eona e eketsa palo ea li-receptor tsa LDL (low-density lipoprotein) sebeteng, e thusang ho theola maemo a tlase a LDL, kapa mofuta o mobe oa k'holeseterole, maling.
Ka bobeli pravastatin le atorvastatin li sebetsa ka litsela tse ts'oanang, empa li na le liphapang tse lokelang ho elelloa.
Phapang e kholo ke efe lipakeng tsa pravastatin le Lipitor?
Pravastatin ke lebitso le tloaelehileng la Pravachol. Ho fapana le lithethefatsi tse ling tsa statin, pravastatin ha e sebelisoe haholo, kapa ho sebetsoa, ke li-enzyme tsa CYP3A4 sebeteng. Ho e-na le hoo, pravastatin e joalo robehile ka mpeng .
Matlapa a tlhaho a Pravastatin a fumaneha ka matla a 10 mg, 20 mg, 40 mg, le 80 mg. Pravastatin hangata e laeloa hore e nkuoe hang ka letsatsi mantsiboea. Ho bonts'itsoe hore pravastatin e sebetsa hantle ha e nkuoa mantsiboea hofeta hoseng.
Lipitor ke moriana o bitsoang lebitso la mofuta 'me o fumaneha ka mofuta oa generic o bitsoang atorvastatin. Ho fapana le pravastatin, atorvastatin e sebetsoa haholo ke enzyme ea CYP3A4 sebeteng. Ka hona, atorvastatin e kanna ea sebelisana le meriana e mengata ho feta pravastatin.
Lipitor e fumaneha matlapeng a molomo ka matla a 10 mg, 20 mg, 40 mg, le 80 mg. Lipitor e ka nkoa hoseng kapa mantsiboea, 'me hangata e nooa hanngoe ka letsatsi.
| Phapang e kholo lipakeng tsa pravastatin le Lipitor | ||
|---|---|---|
| Lerato | Lipitor | |
| Sehlopha sa lithethefatsi | HMG-CoA reductase inhibitor | HMG-CoA reductase inhibitor |
| Boemo ba cha / cha | Mofuta oa brand le generic oa fumaneha | Mofuta oa brand le generic oa fumaneha |
| Lebitso la generic ke mang? Lebitso la lebitso ke mang? | Lebitso la lebitso: Pravachol Lebitso la tlhaho: Pravastatin | Lebitso la Brand: Lipitor Lebitso la tlhaho: Atorvastatin |
| Sethethefatsi se kena ka mefuta e fe? | Letlapa la molomo | Letlapa la molomo |
| Tekanyo e tloaelehileng ke efe? | 10 ho isa ho 80 mg hang ka letsatsi | 10 ho isa ho 80 mg hang ka letsatsi |
| Kalafo e tloaelehileng e nka nako e kae? | Nako e telele | Nako e telele |
| Ke mang ea sebelisang meriana eo? | Batho ba baholo; bana le bacha ba lilemo li 8 ho isa ho tse 18 | Batho ba baholo; bana le bacha ba lilemo li 10 ho isa ho tse 17 |
Maemo a tšoaroang ke pravastatin le Lipitor
Pravastatin le atorvastatin li ka thusa ho fokotsa menyetla ea ho hlaseloa ke pelo le lichapo bathong ba nang le lefu la pelo. Meriana ena ka bobeli e ka thusa ho fokotsa kotsi ea lefu ho tsoa lefu la pelo . Lisosa tse kotsi tsa lefu la pelo li kenyelletsa khatello e phahameng ea mali, ho tsuba le maemo a phahameng a k'holeseterole.
Ka bobeli pravastatin le atorvastatin ke FDA e lumelletsoeng ho fokotsa maemo a phahameng a cholesterol le LDL (e tsejoang hape e le hyperlipidemia kapa hypercholesterolemia). Meriana ea Statin e ka thusa ho phekola maemo a phahameng a triglycerides , e leng mofuta o mong oa mafura kapa lipids 'meleng. Motho ea nang le maemo a phahameng a triglycerides o na le hypertriglyceridemia.
Pravastatin le Lipitor le tsona li ka eketsa maemo a HDL maling. Cholesterol ea HDL ke se tsejoang e le cholesterol e ntle maling.
| Boemo | Lerato | Lipitor |
| Hyperlipidemia | Ho joalo | Ho joalo |
| Hypercholesterolemia | Ho joalo | Ho joalo |
| Hypertriglyceridemia | Ho joalo | Ho joalo |
Na pravastatin kapa Lipitor e sebetsa hantle?
Ka bobeli pravastatin le atorvastatin ke meriana e sebetsang bakeng sa ho phekola k'holeseterole e phahameng ea mali. Moriana o sebetsang ka ho fetisisa o latela boemo ba hau ka kakaretso, ho teba ha boemo ba hau, lithethefatsi tse ling tseo o kanna oa li nka le lintlha tse ling.
E le 'ngoe thuto e bapisang re fumane hore ha ho na phapang e kholo lipakeng tsa pravastatin, simvastatin, le atorvastatin bakeng sa ho thibela liketsahalo tsa pelo. Ka mantsoe a mang, lithethefatsi tsena tsa statin le tsona li ne li sebetsa ka mokhoa o ts'oanang ho fokotsa litlhaselo tsa pelo le lefu la pelo.
HO tlhahlobo e hlophisehileng e kopantseng liteko tse fetang 90 tsa bongaka li bapisa lithethefatsi tsa statin tse kang fluvastatin, atorvastatin, pravastatin, simvastatin le rosuvastatin. Tlhahlobo e phethile ka hore atorvastatin, fluvastatin, le simvastatin li na le monyetla o moholo ka ho fetisisa oa ho ba kalafo e ntle ka ho fetisisa ea ho thibela liketsahalo tsa pelo.
Ikopanye le mofani oa tlhokomelo ea bophelo ho fumana hore na sethethefatsi se nepahetseng ka ho fetesisa seo u ka se sebelisang. Kamora ho etsa tlhahlobo ea mali le ho lekola boemo ba hau ka kakaretso, mofani oa thepa o tla tseba hore na pravastatin kapa atorvastatin ke setlhare se sebetsang hantle ho uena. Ba kanna ba fana ka sethethefatsi se fapaneng sa statin joalo ka Zocor (simvastatin) kapa Crestor (rosuvastatin).
Ho bapisa le ho bapisa litšenyehelo tsa pravastatin vs Lipitor
Pravastatin ke meriana e tloaelehileng e atisang ho koaheloa ke Medicare le merero ea inshorense. Theko ea karolelano ea chelete ea pravastatin e ka ba $ 129.99 bakeng sa phepelo ea matsatsi a 30. Karete ea ho boloka ea SingleCare e ka khona ho theola litšenyehelo tsa lengolo la ngaka la pravastatin ho ea tlase ho $ 15.
Lipitor ke moriana oa lebitso le fumanehang hape ka theko e theko e tlaase. Mofuta o tloaelehileng oa Lipitor, atorvastatin, hangata o koaheloa ke boholo ba Medicare le merero ea inshorense. Lebitso la lebitso la Lipitor le ka koaheloa ke merero ea inshorense ka copay e phahameng. Theko ea chelete ea Lipitor e haufi le $ 249.99. Li-coupon tsa SingleCare li ka theola litšenyehelo ho isa ho $ 15 li-pharmacy tse nkang karolo.
| Lerato | Lipitor | |
| E koahetsoe ka inshorense? | Ho joalo | Ho joalo |
| E koahetsoe ka tloaelo ke Medicare Part D? | Ho joalo | Ho joalo |
| Bongata | Matlapa a 30 (40 mg) | Matlapa a 30 (40 mg) |
| E tloaelehileng ea Medicare copay | $ 0- $ 20 | $ 0- $ 16 |
| Litsenyehelo tsa SingleCare | $ 12 + | $ 15 + |
Litla-morao tse tloaelehileng tsa pravastatin vs. Lipitor
Litla-morao tse atileng haholo tsa pravastatin ke bohloko ba mesifa kapa mesifa, ho nyekeloa ke pelo, ho hlatsa, letshollo le hlooho. Litla-morao tse atileng haholo tsa atorvastatin ke mesifa ea mesifa le mesifa, letshollo le bohloko ba manonyeletso (arthralgia). Ka bobeli pravastatin le atorvastatin le tsona li ka baka litla-morao tse ling tse kang ho nyehlisa, ho tsekela, mokhathala, ho phatloha le tšoaetso ea mosese.
E tebileng litla-morao tsa lithethefatsi tsa statin kenyeletsa lefu la mesifa (myopathy) le ho senyeha ka potlako ha lisele tsa mesifa (rhabdomyolysis). Ikopanye le mofani oa tlhokomelo ea bophelo hanghang ha o ba le bohloko ba mesifa bo phehellang kapa bo sa hlaloseheng, bofokoli kapa bonolo.
Pravastatin le atorvastatin le tsona li ka baka li-enzyme tse phahameng tsa sebete. Maemo a enzyme ea sebete a ka hloka ho hlahlojoa pele le ho lekoa nakong eohle ea kalafo.
| Lerato | Lipitor | |||
| Phello e lehlakoreng | E sebetsa? | Maqhubu | E sebetsa? | Maqhubu |
| Bohloko ba mesifa | Ho joalo | 10% | Ho joalo | 4% |
| Ho nyekeloa ke pelo / ho hlatsa | Ho joalo | 7% | Ho joalo | 4% |
| Letšollo | Ho joalo | 7% | Ho joalo | 7% |
| Qoqelo | Ho joalo | 3% | Ho joalo | 5% |
| Botsoa | Ho joalo | 4% | Ho joalo | * |
| Ho opeloa ke hlooho | Ho joalo | 6% | Che | - |
| Mokhathala | Ho joalo | 3% | Ho joalo | * |
| Moferefere | Ho joalo | 5% | Ho joalo | * |
| Arthralgia | Ho joalo | * | Ho joalo | 7% |
| Tšoaetso ea pampiri ea moroto | Ho joalo | 3% | Ho joalo | 6% |
Maqhubu ha a ipapise le tlhaiso-leseling e tsoang hloohong ho ea hloohong. Sena e kanna ea se be lenane le felletseng la litlamorao tse bohloko tse ka bang teng. Ka kopo sheba ngaka ea hau kapa mofani oa tlhokomelo ea bophelo ho ithuta haholoanyane.
Mohloli: DailyMed ( Lerato ), DailyMed ( Lipitor )
* ha e tlalehe
Likamano tsa lithethefatsi tsa pravastatin vs. Lipitor
Pravastatin le atorvastatin li sebelisana le meriana e tšoanang. Leha ho le joalo, kaha atorvastatin e sebelisoa haholo-holo ke enzyme ea CYP3A4 sebeteng, e kanna ea sebelisana le lithethefatsi tse ling tse amang li-enzyme tsa CYP3A4 sebeteng.
Ho noa meriana e kang cyclosporine, clarithromycin, kapa ritonavir e nang le pravastatin kapa atorvastatin ho ka lebisa maemong a eketsehileng a li-statin maling, tse ka eketsang kotsi ea litlamorao.
Li-antacids li ka kena-kenana le ho monya meriana ea li-statin le ho fokotsa ts'ebetso ea tsona. Tsamaiso ea li-antacids le li-statin e lokela ho aroloa bonyane lihora tse peli. Cholestyramine e ka fokotsa ho monya le ho sebetsa hantle ha li-statin. Tsamaiso ea cholestyramine le li-statin li lokela ho aroloa ka lihora tse 'ne.
Niacin le fibrate li ka eketsa kotsi ea myopathy le rhabdomyolysis ha e nkuoa ka pravastatin kapa atorvastatin.
Ts'ebeliso ea atorvastatin e lokela ho qojoa kapa ho beoa leihlo ha e ntse e sebelisoa Lero la morara . Lero la tholoana ea morara le sebetsa joalo ka CYP3A4 inhibitor e ka lebisang maemong a eketsehileng a atorvastatin maling le ho eketsa kotsi ea litla-morao.
| Lithethefatsi | Sehlopha sa lithethefatsi | Lerato | Lipitor |
| Cyclosporine | Li-immunosuppressants | Ho joalo | Ho joalo |
| Clarithromycin Erythromycin | Lithibela-mafu | Ho joalo | Ho joalo |
| Ketoconazole Itraconazole Voriconazole Posaconazole | Likokoana-hloko | Che | Ho joalo |
| Ritonavir Simeprevir Ledipasvir Boceprevir Darunavir | Lithibela-mafu | Ho joalo | Ho joalo |
| Niacin | Baemeli ba likokoana-hloko | Ho joalo | Ho joalo |
| Fenofibrate Gemfibrozil | Likhoele | Ho joalo | Ho joalo |
| Digoxin | Li-glycosides tsa pelo | Ho joalo | Ho joalo |
| Cholestyramine | Li-sequestrants tsa acid | Ho joalo | Ho joalo |
| Aluminium hydroxide Magnesium hydroxide | Likokoana-hloko | Ho joalo | Ho joalo |
Ikopanye le setsebi sa tlhokomelo ea bophelo bakeng sa litšebelisano tse ling tsa lithethefatsi.
Litemoso tsa pravastatin le Lipitor
Pravastatin le atorvastatin li lokela ho qojoa ho ba nang le lefu la sebete kapa mafura a phahameng a enzyme ea sebete. Meriana ea Statin e ka baka tšenyo e eketsehileng ea sebete ho motho ea nang le lefu la sebete.
Pravastatin le atorvastatin ha lia lokela ho sebelisoa ho ba nang le nalane ea boits'oaro ba hypersensitivity meriana ea statin. Matšoao a ts'oaetso ea hypersensitivity a kenyelletsa ho phatloha, ho hlohlona, ho ruruha le bothata ba ho hema.
Meriana ea Statin e na le kotsi ea tšenyo e mpe ea mesifa le bohloko ba mesifa. Ho ka ba le kotsi e eketsehileng ea bohloko ba mesifa ho ba ka holimo ho lilemo tse 65 kapa ba nang le ts'oaetso e sa laoleheng ea hypothyroidism kapa liphio.
Pravastatin le atorvastatin ha lia lokela ho sebelisoa ho baimana kapa ba anyesang.
Bua le mofani oa tlhokomelo ea bophelo ho bua ka litemoso tse ling tse ka bang teng kapa litemoso tse amanang le pravastatin kapa atorvastatin.
Lipotso tse botsoang khafetsa ka pravastatin vs. Lipitor
Pravastatin ke eng?
Pravastatin ke moriana o tloaelehileng o sebelisetsoang ho theola k'holeseterole le ho thibela mathata a bakoang ke maemo a phahameng a k'holeseterole. Lebitso la pravastatin ke Pravachol. E laeloa hore e nkuoe hang ka letsatsi mantsiboea. Pravastatin e fumaneha e le letlapa la molomo.
Lipitor ke eng?
Lipitor ke moriana o bitsoang lebitso la brand o entsoeng ke Pfizer. Lebitso le tloaelehileng la Lipitor ke atorvastatin. E sebelisetsoa ho phekola maemo a phahameng a k'holeseterole le ho fokotsa kotsi ea tlhaselo ea pelo le stroke. Lipitor e laeloa hore e nkuoe hang ka letsatsi hoseng kapa mantsiboea. E fumaneha joalo ka letlapa la molomo.
Na pravastatin le Lipitor lia tšoana?
Ka bobeli pravastatin le atorvastatin ke meriana e sebelisoang ho fokotsa maemo a phahameng a k'holeseterole. Leha ho le joalo, ha li tšoane. Atorvastatin e sebelisoa haholo-holo ke sistimi ea enzyme ea CYP P450 sebeteng ha pravastatin e robehile ka mpeng. Pravastatin hangata e nkoa bosiu ha Lipitor e nkoa hoseng kapa mantsiboea.
Na pravastatin kapa Lipitor li betere?
Ka bobeli pravastatin le Lipitor ke mefuta e sebetsang ea kalafo ea statin. Meriana ena ka bobeli e ka thusa ho thibela mathata a k'holeseterole e phahameng, joalo ka atherosclerosis, lefu la pelo le stroke. Lithuto tse ling tsa likoranta tsa lefu la pelo ba fumane hore atorvastatin, motsoako o sebetsang ho Lipitor, o sebetsa hantle ho feta lithethefatsi tse ling tsa statin bakeng sa ho thibela liketsahalo tsa pelo le methapo joaloka lefu la pelo le stroke. Mofani oa tlhokomelo ea bophelo a ka u fa likeletso tsa bongaka ka litlhare tse molemohali tsa statin bakeng sa hau.
Na nka sebelisa pravastatin kapa Lipitor ha ke le moimana?
Pravastatin le atorvastatin ha li khothalletsoe hore li nooe ha li le moimana. Meriana ena ka bobeli e na le kotsi e kholo ea ho baka likoli tsa tlhaho. Ikopanye le mofani oa tlhokomelo ea bophelo bo botle mabapi le kalafo e ntle ka ho fetisisa ea k'holeseterole e phahameng ha o le moimana.
A na nka sebelisa pravastatin kapa Lipitor ka joala?
Ha ho na kotsi e kholo ea bophelo bo botle e amehang ka tšebeliso e itekanetseng ea joala le li-statin. Lithethefatsi tsa Statin le tšebeliso e feteletseng ea joala e ka senya sebete . Bua le mofani oa tlhokomelo ea bophelo ho lekola hore na ho bolokehile hore u noe joala ha u ntse u noa moriana oa 'statin'.
